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Botulism is often a neuroparalytic disease characterised by symmetric, descending flaccid paralysis of motor and autonomic nerves, usually starting with the cranial nerves.On Oct 15, 2010, the US FDA approved onabotulinumtoxinA (BOTOX®) injection to prevent head aches in Grownup patients with Continual migraine. Persistent migraine is outlined as

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